First report of acute, visceral, fatal toxoplasmosis in a naturally infected calf (Bos taurus).

IF 2 2区农林科学 Q2 PARASITOLOGY

Veterinary parasitology Pub Date : 2024-12-07 DOI:10.1016/j.vetpar.2024.110373

Jitender P Dubey, Alan F Julian

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引用次数: 0

Abstract

Cattle are considered resistant to clinical toxoplasmosis and viable Toxoplasma gondii is rarely isolated from bovine tissues. Currently, there is no histologically confirmed case of clinical toxoplasmosis in cattle. Here, the first confirmed case of acute toxoplasmosis in cattle is reported. A calf from New Zealand died of acute toxoplasmosis in 2012. Severe lesions were found in the intestinal mesentery and mesenteric lymph nodes. The mesenteric lymph nodes were edematous, and necrosis affected the entire parenchyma including blood vessels, associated with enormous numbers of tachyzoites. Lesions in liver were inflammatory, affecting periportal areas and central veins. Some hepatocytes were engorged with tachyzoites, and tissue cysts were present in the parenchyma. Focal pneumonitis and nephritis were associated with tachyzoites. Tachyzoites were seen in bronchioles, in renal glomeruli and in renal tubules. Diagnosis was confirmed immunohistochemically using T. gondii specific antibodies, but not Neospora caninum -specific antibodies. The presence of numerous tissue cysts was confirmed by immunohistochemical staining with bradyzoite-specific T. gondii antibodies (BAG1).

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在一头自然感染的小牛（Bos taurus）中首次报道急性、内脏、致命的弓形虫病。

牛被认为对临床弓形虫病具有抵抗力，并且很少从牛组织中分离出有活力的刚地弓形虫。目前，在牛中没有组织学证实的临床弓形虫病病例。在这里，报告了首例牛急性弓形虫病确诊病例。2012年，新西兰的一头小牛死于急性弓形虫病。严重病变见于肠系膜及肠系膜淋巴结。肠系膜淋巴结水肿，坏死累及整个实质，包括血管，伴大量速殖子。肝脏病变为炎性，影响门静脉周围和中央静脉。部分肝细胞充盈速殖子，实质内可见组织囊肿。局灶性肺炎和肾炎与速殖子有关。细支气管、肾小球和肾小管可见速殖子。使用弓形虫特异性抗体而非犬新孢子虫特异性抗体进行免疫组化诊断。通过慢殖子特异性弓形虫抗体（BAG1）免疫组化染色证实存在大量组织囊肿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary parasitology 农林科学-寄生虫学

CiteScore

5.30

自引率

7.70%

发文量

126

审稿时长

36 days

期刊介绍： The journal Veterinary Parasitology has an open access mirror journal,Veterinary Parasitology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. This journal is concerned with those aspects of helminthology, protozoology and entomology which are of interest to animal health investigators, veterinary practitioners and others with a special interest in parasitology. Papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites in all domesticated animals, fall within the scope of the journal. Papers of geographically limited (local) interest which are not of interest to an international audience will not be accepted. Authors who submit papers based on local data will need to indicate why their paper is relevant to a broader readership. Parasitological studies on laboratory animals fall within the scope of the journal only if they provide a reasonably close model of a disease of domestic animals. Additionally the journal will consider papers relating to wildlife species where they may act as disease reservoirs to domestic animals, or as a zoonotic reservoir. Case studies considered to be unique or of specific interest to the journal, will also be considered on occasions at the Editors'' discretion. Papers dealing exclusively with the taxonomy of parasites do not fall within the scope of the journal.