Bursts of brain erosion: seizures and age-dependent neurological vulnerability.

IF 12.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Noemie Cresto, Laurent Givalois, Jerome Badaut, Alicia Janvier, Athenais Genin, Etienne Audinat, Amy L Brewster, Nicola Marchi
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引用次数: 0

Abstract

Hypersynchronous and exaggerated neuronal firing, exemplified by epileptiform activity and seizures, are disruptors of brain function across acute and chronic neuropathological conditions. Here, we focus on how seizure activity, whether as a primary symptom or a secondary comorbid event within a complex pathological setting, adversely impacts neurological trajectories. We discuss experimental and clinical evidence illustrating the participation of neurodegenerative and senescence-like adaptations. Paroxysmal neuronal events, through bidirectional causality, are linked with immune and microvascular changes, disrupting cellular homeostasis and creating a feed-forward loop that intertwines with age-related frailty to deteriorate mental health. We emphasize the clinical significance of early detection of these brain vulnerabilities through biomarkers, monitoring neurodevelopmental risks in children, and tracking neurodegenerative disease progression in aging populations.

突发脑侵蚀:癫痫发作和年龄依赖性神经系统脆弱性。
过度同步和夸张的神经元放电,例如癫痫样活动和癫痫发作,是急性和慢性神经病理条件下脑功能的干扰物。在这里,我们关注癫痫活动,无论是作为主要症状还是作为复杂病理环境中的继发性共病事件,如何对神经系统轨迹产生不利影响。我们讨论的实验和临床证据说明参与神经退行性和衰老样适应。通过双向因果关系,突发性神经元事件与免疫和微血管变化有关,破坏细胞稳态,并形成一个与年龄相关的脆弱交织在一起的前馈循环,从而恶化心理健康。我们强调通过生物标志物早期检测这些脑脆弱性、监测儿童神经发育风险以及追踪老年人群神经退行性疾病进展的临床意义。
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来源期刊
Trends in molecular medicine
Trends in molecular medicine 医学-生化与分子生物学
CiteScore
24.60
自引率
0.00%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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