A Case of Pseudoelevation of Serum HCG Caused by Rheumatoid Factor.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2024-12-01 DOI:10.7754/Clin.Lab.2024.240737

Gangfeng Li, Ningping Shan, Hu Chen

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引用次数: 0

Abstract

Background: Serum human chorionic gonadotropin (HCG) is a glycoprotein hormone secreted by the trophoblast cells of the placenta. HCG levels are helpful in confirming and monitoring pregnancy, as well as in the diagnosis and monitoring of trophoblastic tumors. Therefore, the accuracy of HCG detection results is of great significance for the diagnosis and differential diagnosis of pregnancy and germ cell tumors.

Methods: We report a case of pseudo elevation of serum HCG in a patient with rheumatoid arthritis. The possibility of abnormal increase in HCG concentration caused by rheumatoid factor (RF) was evaluated using polyethylene glycol (PEG) precipitation method and different detection platforms.

Results: Samples pretreated with polyethylene glycol and samples using another detection platform showed a significant decrease in serum HCG concentration and a negative reaction. Therefore, the patient's HCG result showed an abnormal increase, which is considered a false increase caused by RF interference.

Conclusions: When serum HCG levels are abnormally elevated in patients with rheumatoid arthritis but there is no evidence of pregnancy or clinical symptoms related to trophoblastic tumors, staff should consider the possibility of RF interference in HCG detection, take corresponding corrective measures, and communicate with clinical doctors in a timely manner.

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类风湿因子所致血清HCG假性升高1例。

背景：血清人绒毛膜促性腺激素（HCG）是一种由胎盘滋养细胞分泌的糖蛋白激素。HCG水平有助于确认和监测妊娠，以及滋养细胞肿瘤的诊断和监测。因此，HCG检测结果的准确性对妊娠和生殖细胞肿瘤的诊断和鉴别诊断具有重要意义。方法：我们报告一例类风湿关节炎患者血清HCG假性升高。采用聚乙二醇（PEG）沉淀法及不同检测平台，评价类风湿因子（RF）引起HCG浓度异常升高的可能性。结果：经聚乙二醇预处理的样品和采用其他检测平台的样品血清HCG浓度明显下降，呈阴性反应。因此，患者HCG结果出现异常升高，考虑为射频干扰引起的假升高。结论：当类风湿关节炎患者血清HCG水平异常升高，但无妊娠证据或与滋养层肿瘤相关的临床症状时，工作人员应考虑射频干扰HCG检测的可能性，采取相应的纠正措施，并及时与临床医生沟通。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.