Cytokines in cancer

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-12-12 DOI:10.1016/j.ccell.2024.11.011

Courtney T. Kureshi, Stephanie K. Dougan

引用次数: 0

Abstract

Cytokines are proteins used by immune cells to communicate with each other and with cells in their environment. The pleiotropic effects of cytokine networks are determined by which cells express cytokines and which cells express cytokine receptors, with downstream outcomes that can differ based on cell type and environmental cues. Certain cytokines, such as interferon (IFN)-γ, have been clearly linked to anti-tumor immunity, while others, such as the innate inflammatory cytokines, promote oncogenesis. Here we provide an overview of the functional roles of cytokines in the tumor microenvironment. Although we have a sophisticated understanding of cytokine networks, therapeutically targeting cytokine pathways in cancer has been challenging. We discuss current progress in cytokine blockade, cytokine-based therapies, and engineered cytokine therapeutics as emerging cancer treatments of interest.

查看原文本刊更多论文

癌症中的细胞因子

细胞因子是免疫细胞相互之间以及与环境中的细胞进行交流的蛋白质。细胞因子网络的多效性取决于哪些细胞表达细胞因子，哪些细胞表达细胞因子受体，其下游结果可能根据细胞类型和环境线索而不同。某些细胞因子，如干扰素(IFN)-γ，已经明确地与抗肿瘤免疫有关，而其他细胞因子，如先天炎症细胞因子，则促进肿瘤的发生。在这里，我们提供细胞因子在肿瘤微环境中的功能作用的概述。尽管我们对细胞因子网络有了复杂的了解，但在癌症中靶向细胞因子通路的治疗一直具有挑战性。我们讨论了当前在细胞因子阻断、细胞因子为基础的治疗和工程细胞因子治疗等新兴癌症治疗方面的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.