{"title":"The role of the sulfaguanidine molecular scaffold in drug design and development.","authors":"Hamada S Abulkhair","doi":"10.1002/ardp.202400802","DOIUrl":null,"url":null,"abstract":"<p><p>Developing new molecular entities is one of the most emerging research areas in the field of Medicinal Chemistry. Over the past few years, rigorous research has been conducted on sulfaguanidine-linked synthetic molecules because of their promising potential in several biological activities. Sulfaguanidine has been actively incorporated in the design of anticancer, antimicrobial, antidiabetic, antiparkinsonian, anti-inflammatory, and antiviral candidates. The construction of these effective candidates has adopted many chemical approaches. A number of the prepared compounds displayed promising results that merit further investigations for the development of new medications. This review summarizes the different chemical strategies and the reported activities for sulfaguanidine-linked synthetic molecules throughout 2020-2024.</p>","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":" ","pages":"e2400802"},"PeriodicalIF":4.3000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archiv der Pharmazie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ardp.202400802","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Developing new molecular entities is one of the most emerging research areas in the field of Medicinal Chemistry. Over the past few years, rigorous research has been conducted on sulfaguanidine-linked synthetic molecules because of their promising potential in several biological activities. Sulfaguanidine has been actively incorporated in the design of anticancer, antimicrobial, antidiabetic, antiparkinsonian, anti-inflammatory, and antiviral candidates. The construction of these effective candidates has adopted many chemical approaches. A number of the prepared compounds displayed promising results that merit further investigations for the development of new medications. This review summarizes the different chemical strategies and the reported activities for sulfaguanidine-linked synthetic molecules throughout 2020-2024.
期刊介绍：
Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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