Porcine Corneal Injuries and Investigation of Damage Thresholds of High-Frequency Terahertz Wave

IF 1.3 4区物理与天体物理 Q3 PHYSICS, FLUIDS & PLASMAS

IEEE Transactions on Plasma Science Pub Date : 2024-11-13 DOI:10.1109/TPS.2024.3403722

Hao Lin;Pan Liu;Wenzai An;Xin Yan;Shen Wu;Ningli Wang

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Abstract

The objective was to investigate immediate ocular damage in exposed to 34.5-terahertz (THz) electromagnetic wave generated by quantum cascade laser (QCL). This research developed the damage porcine model for THz exposure, and its damage occurrence threshold values of time dimension and energy dimension were obtained. The right eyes were exposed to 34.5-THz spot from fiber, and the contralateral eyes were used as control eyes. Slit-lamp examination 5 min after THz exposure revealed a semicircular area of opacity characterized by fluorescein staining, indicating damaged corneal epithelial cells in the irradiated area and encircling by corneal edema. Hematoxylin-eosin (HE) staining suggested the irradiated corneas over 2 min exposure contained fewer epithelial cell layers with vacuolated cells, swollen endothelium, and edematous stroma, compared to contralateral corneas. In vivo evidence suggested exposure time over 6 min or energy over 40 mW leaded to full-thickness detachment of the corneal epithelium. The damage was present when the energy of THz wave was greater than 20 mW or the exposure time was longer than 2 min.

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猪角膜损伤及高频太赫兹波损伤阈值研究

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来源期刊

IEEE Transactions on Plasma Science 物理-物理：流体与等离子体

CiteScore

3.00

自引率

20.00%

发文量

538

审稿时长

3.8 months

期刊介绍： The scope covers all aspects of the theory and application of plasma science. It includes the following areas: magnetohydrodynamics; thermionics and plasma diodes; basic plasma phenomena; gaseous electronics; microwave/plasma interaction; electron, ion, and plasma sources; space plasmas; intense electron and ion beams; laser-plasma interactions; plasma diagnostics; plasma chemistry and processing; solid-state plasmas; plasma heating; plasma for controlled fusion research; high energy density plasmas; industrial/commercial applications of plasma physics; plasma waves and instabilities; and high power microwave and submillimeter wave generation.