Therapeutic Efficacy of Tirofiban Combined With Thrombus Aspiration and Stent Thrombectomy in the Treatment of Large Vessel Occlusion Ischemic Stroke.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY

Neurologist Pub Date : 2024-12-06 DOI:10.1097/NRL.0000000000000603

Yang Jiao, Xiaoli Wang, Yaxin Guan, Xinxin Wang, Zhaosheng Li, Xiuzhi Xiang, Zhongmin Zhang

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引用次数: 0

Abstract

Objective: This research aimed to ascertain the effects of tirofiban combined with thrombus aspiration and stent thrombectomy on large vessel occlusion ischemic stroke (LVO-IS).

Methods: Sixty patients with acute ischemic stroke (AIS) caused by LVO were randomized into the control group and the intervention group (n=30). Patients in the control group received thrombus aspiration combined with stent thrombectomy, while those in the intervention group were treated with tirofiban combined with thrombus aspiration and stent thrombectomy. General data, perioperative-related indicators, cerebral blood flow perfusion, coagulation function indicators, and neurological function indicators were collected, and the prognosis was observed after 3-month treatment.

Results: A comparison of symptomatic cerebral hemorrhage rate and hospital mortality rate between the 2 groups displayed no significant difference (P>0.05). The rate of revascularization in the intervention group (90.00%) was higher versus the control group (66.67%). After treatment, the mean blood flow and cerebral blood volume of the intervention group were higher and the time to peak cerebral blood flow was less versus the control group. The prothrombin time, activated partial thromboplastin time, and prothrombinogen time of the intervention group were higher, and fibrinogen was lower versus the control group. A lower National Institutes of Health Stroke Scale score was observed in the intervention group versus the control group.

Conclusions: Tirofiban combined with thrombus aspiration and stent thrombectomy has good efficacy in LVO-IS patients.

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研究目的本研究旨在确定替罗非班联合血栓抽吸术和支架血栓切除术对大血管闭塞性缺血性脑卒中（LVO-IS）的影响：方法：将60例由LVO引起的急性缺血性脑卒中（AIS）患者随机分为对照组和干预组（30例）。对照组患者接受血栓抽吸术联合支架血栓切除术，干预组患者接受替罗非班联合血栓抽吸术和支架血栓切除术。收集一般资料、围手术期相关指标、脑血流灌注、凝血功能指标和神经功能指标，观察治疗3个月后的预后情况：结果：两组无症状脑出血率和住院死亡率比较差异无显著性（P>0.05）。干预组的血管再通率（90.00%）高于对照组（66.67%）。与对照组相比，干预组治疗后的平均血流量和脑血量更高，达到峰值脑血流量的时间更短。与对照组相比，干预组的凝血酶原时间、活化部分凝血活酶时间和凝血酶原时间更长，纤维蛋白原更低。干预组的美国国立卫生研究院卒中量表评分低于对照组：结论：替罗非班联合血栓抽吸术和支架血栓切除术对 LVO-IS 患者有很好的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologist 医学-临床神经学

CiteScore

1.90

自引率

0.00%

发文量

151

审稿时长

2 months

期刊介绍： The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.