[A Case of Pyoderma Gangrenosum Associated with Metastatic Breast Cancer-A Case Report].

Abstract

Pyoderma gangrenosum(PG)is a rare skin disorder and its diagnosis is often delayed owing to its wound infection mimicking course. A 50-year-old woman presented to our hospital with multiple liver and bone metastases from breast cancer. A port was created on her right upper arm to administer chemotherapy. Although this treatment was successful, the port wound disrupted 10 months after treatment initiation. An infection was suspected, the port was removed, and chemotherapy was discontinued. However, another ulcer with necrotic tissue was observed in the right inguinal region. Skin biopsy revealed dense infiltration of neutrophils into the epidermis and dermis. The patient was administered prednisolone 30 mg/ day, and both wounds recovered. This case shows that, when skin necrotic ulcers are observed in patients with cancer, PG must be considered as a differential diagnosis.