Regulation and application of m6A modification in tumor immunity.

Abstract

The m⁶A modification is an RNA modification that impacts various processes of RNA molecules, including transcription, splicing, stability, and translation. Recently, researchers have discovered that the presence of m⁶A modification can influence the interaction between tumor cells and immune cells and also play a role in regulating the expression of immune response-related genes. Additionally, m⁶A modification is intricately involved in the regulation of tumor immune evasion and drug resistance. Specifically, certain tumor cells can manipulate the gene expression through m⁶A modification to evade immune system attacks. Therefore, it might be possible to enhance tumor immune surveillance and improve the effectiveness of immune-based therapies by manipulating m⁶A modification. This review systematically discusses the role of m⁶A modification in tumor immunity, specifically highlighting its regulation of immune cells and immune-related genes in tumor cells. Furthermore, we explore the potential of m⁶A modification inhibitors as anti-cancer therapies and the significance of m⁶A regulatory factors in predicting the efficacy of tumor immune therapy.