Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Qing Liu, Jian Liu, Guanglei Cao, Yuan Liu, Ye Huang, Xieyuan Jiang
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引用次数: 0

Abstract

Medical ozone is a molecule composed of three oxygen atoms with anti-inflammatory, analgesic, and antioxidant functions. Ozone therapy (O3 or O2- O3) for knee osteoarthritis has gradually received increasing attention from researchers in recent years. Here, we discuss the research hotspots and development trends of ozone therapy for knee osteoarthritis through literature visualization and analysis. (1) From 2012 to the present, the overall trend of publications on ozone treatment for knee osteoarthritis has been increasing annually, and it has received widespread attention, especially in Iran and China. (2) Keyword analysis revealed that the keywords with the greatest number of citations for ozone treatment of knee osteoarthritis are "osteoarthritis," "ozone," "knee osteoarthritis," "ozone therapy," and "hyaluronic acid." (3) The results of the cocitation analysis revealed that the themes of the cocited literature are concentrated in 11 directions: intra-articular injections, intra-articular oxygen ozone, treatment of knee osteoarthritis, rehabilitation studies, time effects, pain function, comprehensive review, growth factors, rheumatic diseases, ultrasound-guided corticosteroid injections, and placebo. (4) The hotspots of the available highly cited literature have focused mainly on the efficacy and safety of ozone or growth factors alone in the treatment of knee osteoarthritis. Most of the literature suggests that intra-articular injections are the most common form of ozone therapy, and the accuracy and safety of ozone injections can be ensured using ultrasound-guided techniques. Ozone therapy has a positive short-term effect on pain control and functional recovery within 6 months after injection, but how to maintain the long-term efficacy of ozone therapy has rarely been described. It is hypothesized that the combination of ozone and growth factors may be beneficial for prolonging the efficacy of ozone therapy. (5) Ozone therapy has no advantages over other therapies in terms of therapeutic efficacy. Compared with ozone therapy, platelet-rich plasma and growth factor-rich plasma have better long-term outcomes in the treatment of knee osteoarthritis, whereas stromal vascular components have the best effects on pain relief and functional improvement. Few studies address the combination of ozone and growth factors for the treatment of knee osteoarthritis, and a few clinical studies registered have explored other treatments (e.g., corticosteroids). (6) Future studies could further explore the specific mechanisms and optimal dosing regimens of ozone combined with different growth factors in the treatment of knee osteoarthritis to compensate for the short-term efficacy of ozone therapy and to validate the long-term efficacy and safety of this combination therapy. It is also imperative to develop international guidelines for ozone therapy for osteoarthritis of the knee as soon as possible.

医用臭氧是一种由三个氧原子组成的分子,具有消炎、镇痛和抗氧化功能。近年来,臭氧疗法(O3 或 O2- O3)治疗膝骨关节炎逐渐受到研究者的关注。在此,我们通过文献可视化分析,探讨臭氧治疗膝骨关节炎的研究热点和发展趋势。(1)从2012年至今,有关臭氧治疗膝骨关节炎的文献总体呈逐年上升趋势,尤其在伊朗和中国受到广泛关注。(2)关键词分析显示,臭氧治疗膝骨关节炎被引用次数最多的关键词是 "骨关节炎"、"臭氧"、"膝骨关节炎"、"臭氧治疗 "和 "透明质酸"。(3) 共轭分析结果显示,共轭文献的主题主要集中在 11 个方向:关节内注射、关节内氧 臭氧、膝骨性关节炎的治疗、康复研究、时间效应、疼痛功能、综合评述、生长因子、 风湿性疾病、超声引导下皮质类固醇注射、安慰剂。(4)现有高引用率文献的热点主要集中在臭氧或生长因子单独治疗膝骨关节炎的疗效和安全性上。大多数文献表明,关节内注射是臭氧疗法最常见的形式,使用超声引导技术可以确保臭氧注射的准确性和安全性。臭氧疗法对疼痛控制和注射后 6 个月内的功能恢复有积极的短期效果,但如何保持臭氧疗法的长期疗效却鲜有描述。据推测,臭氧与生长因子的结合可能有利于延长臭氧疗法的疗效。(5) 就疗效而言,臭氧疗法与其他疗法相比没有优势。与臭氧疗法相比,富血小板血浆和富生长因子血浆在治疗膝骨关节炎方面具有更好的长期疗效,而基质血管成分在缓解疼痛和改善功能方面效果最佳。很少有研究涉及臭氧和生长因子联合治疗膝骨关节炎,少数已登记的临床研究还探讨了其他治疗方法(如皮质类固醇)。(6)未来的研究可以进一步探索臭氧与不同生长因子联合治疗膝骨关节炎的具体机制和最佳剂量方案,以弥补臭氧疗法的短期疗效,并验证这种联合疗法的长期疗效和安全性。此外,尽快制定臭氧治疗膝骨关节炎的国际指南也是当务之急。
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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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