Effectiveness and Efficiency Comparison of One-Day vs Eight-Day Methotrexate Protocols in Managing Low-Risk Gestational Trophoblastic Neoplasia.

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI:10.2147/IJWH.S486620

Vidiatma Agbari, Yudi Mulyana Hidayat, Andi Kurniadi, Siti Salima, Ali B Harsono, Dodi Suardi, Hariadi Yuseran, Desy Lisnasari

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引用次数: 0

Abstract

Background: Gestational Trophoblastic Neoplasia (GTN) has a high incidence in Bandung, Indonesia, with a mortality rate between 31% and 51%. The most common type is low-risk GTN with various treatment protocols available. The 8-day Methotrexate (MTX) 50 mg protocol has been implemented at our center; however, due to limitation of government insurance, this study aims to compare its effectiveness against the 1-day Methotrexate (MTX) 300 mg/m² protocol.

Methods: A retrospective cohort study compared two protocols for low-risk GTN treatment at Dr. Hasan Sadikin General Hospital from January 2020 to December 2023: a 1-day Methotrexate (MTX) 300 mg/m² protocol and an 8-day MTX protocol (50 mg MTX IM on days 1, 3, 5, 7 with folinic acid 15 mg orally 24 h after MTX on days 2, 4, 6, 8) and repeat every 2 weeks. Data on patient characteristics, chemotherapy response, side effects, and treatment costs were analyzed.

Results: The 1-day MTX 300 mg/m² protocol achieved similar remission with fewer cycles, milder side effects, and reduced costs compared to the 8-day MTX 50 mg protocol, supporting it as an effective treatment option for low-risk GTN.

Conclusion: The 1-day MTX 300 mg/m² protocol is as an effective treatment option for low-risk GTN compared to the 8-day MTX 50 mg protocol.

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1天与8天甲氨蝶呤治疗低风险妊娠滋养细胞瘤的有效性和效率比较。

背景：妊娠滋养细胞瘤（GTN）在印度尼西亚万隆的发病率很高，死亡率在31%至51%之间。最常见的类型是低风险GTN，有各种治疗方案。本中心已实施8天甲氨蝶呤（MTX） 50 mg方案；然而，由于政府保险的限制，本研究旨在将其与1天甲氨蝶呤（MTX） 300 mg/m²方案的有效性进行比较。方法：一项回顾性队列研究比较了2020年1月至2023年12月哈桑·萨迪金总医院低风险GTN治疗的两种方案：1天甲氨蝶呤（MTX） 300 mg/m²方案和8天MTX方案（MTX第1、3、5、7天服用50 mg MTX，第2、4、6、8天服药后24小时口服15 mg亚叶酸），每2周重复一次。分析了患者特征、化疗反应、副作用和治疗费用的数据。结果：与8天MTX 50 mg方案相比，1天MTX 300 mg/m²方案获得了类似的缓解，周期更短，副作用更轻，成本更低，支持其作为低风险GTN的有效治疗选择。结论：与8天MTX 50 mg方案相比，1天MTX 300 mg/m²方案是低风险GTN的有效治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.