Microbiome-based Therapeutics: Cutting-edge Innovation or Perpetual Promise?

IF 4.8 2区 医学 Q1 UROLOGY & NEPHROLOGY
European urology focus Pub Date : 2024-12-01 Epub Date: 2024-12-07 DOI:10.1016/j.euf.2024.11.008
David J McConkey, Jennifer J Barb, Armine K Smith, Cynthia L Sears
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引用次数: 0

Abstract

Recent preclinical and clinical research has established that the microbiome affects response to immunotherapy, and other work has shown that our diet has strong and rapid effects on the microbiome. Together, these findings have generated strong enthusiasm for the development of therapeutic approaches to exploit these effects. However, inconsistencies in sample collection and data analyses have made it challenging to evaluate the true impact of these interventions. We suggest that the research community needs to develop technical best practices before the true potential of therapeutic microbiome modulation can be realized.

基于微生物组的治疗:前沿创新还是永恒的希望?
最近的临床前和临床研究证实,微生物组会影响对免疫疗法的反应,而其他研究则表明,我们的饮食会对微生物组产生强烈而迅速的影响。这些发现共同激发了人们开发治疗方法以利用这些影响的强烈热情。然而,由于样本收集和数据分析的不一致,评估这些干预措施的真正影响变得十分困难。我们建议,研究界需要开发技术上的最佳实践,然后才能实现微生物组调节疗法的真正潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European urology focus
European urology focus Medicine-Urology
CiteScore
10.40
自引率
3.70%
发文量
274
审稿时长
23 days
期刊介绍: European Urology Focus is a new sister journal to European Urology and an official publication of the European Association of Urology (EAU). EU Focus will publish original articles, opinion piece editorials and topical reviews on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, paediatric urology and sexual medicine. The editorial team welcome basic and translational research articles in the field of urological diseases. Authors may be solicited by the Editor directly. All submitted manuscripts will be peer-reviewed by a panel of experts before being considered for publication.
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