{"title":"Research progress on the pathogenesis of multiple symmetrical lipomatosis.","authors":"Bo Hu, Ze Wang, Tengxiao Ma, Pengfei Fan, Lei Li","doi":"10.1080/21623945.2024.2416681","DOIUrl":null,"url":null,"abstract":"<p><p>Multiple symmetric lipomatosis, also known as madelung's disease, is a rare syndrome characterized by the accumulation of multiple symmetric subcutaneous adipose tissues that significantly affect patients' quality of life. Since the aetiology of the disease is still unclear, surgical intervention by doctors based on clinical experience is currently the main treatment. However, the recurrence rate remains high even after surgical intervention. Therefore, studying the pathogenesis of this disease is particularly important for overcoming this challenge. In this paper, we reviewed and summarized recent research results on the pathogenesis of this disease to provide possible research directions and treatment strategies for this disease, but no clear mechanism was identified.'Level of Evidence: Level I, Review Articles'.</p>","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"13 1","pages":"2416681"},"PeriodicalIF":3.5000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487982/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Adipocyte","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/21623945.2024.2416681","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Multiple symmetric lipomatosis, also known as madelung's disease, is a rare syndrome characterized by the accumulation of multiple symmetric subcutaneous adipose tissues that significantly affect patients' quality of life. Since the aetiology of the disease is still unclear, surgical intervention by doctors based on clinical experience is currently the main treatment. However, the recurrence rate remains high even after surgical intervention. Therefore, studying the pathogenesis of this disease is particularly important for overcoming this challenge. In this paper, we reviewed and summarized recent research results on the pathogenesis of this disease to provide possible research directions and treatment strategies for this disease, but no clear mechanism was identified.'Level of Evidence: Level I, Review Articles'.
期刊介绍：
Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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