Unveiling the nexus: The tumor microenvironment as a strategic frontier in viral cancers

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-01-01 DOI:10.1016/j.cyto.2024.156827

Queenie Fernandes , Oginni Gbenga Folorunsho

引用次数: 0

Abstract

Viral infections are a significant factor in the etiology of various cancers, with the tumor microenvironment (TME) playing a crucial role in disease progression. This review delves into the complex interactions between viruses and the TME, highlighting how these interactions shape the course of viral cancers. We explore the distinct roles of immune cells, including T-cells, B-cells, macrophages, and dendritic cells, within the TME and their influence on cancer progression. The review also examines how viral oncoproteins manipulate the TME to promote immune evasion and tumor survival. Unraveling these mechanisms highlights the emerging paradigm of targeting the TME as a novel approach to cancer treatment. Our analysis provides insights into the dynamic interplay between viruses and the TME, offering a roadmap for innovative treatments that leverage the unique characteristics of viral cancers.

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揭示关系：肿瘤微环境作为病毒性癌症的战略前沿。

病毒感染是各种癌症病因学中的一个重要因素，肿瘤微环境（TME）在疾病进展中起着至关重要的作用。这篇综述深入研究了病毒和TME之间复杂的相互作用，强调了这些相互作用如何塑造病毒癌症的过程。我们探讨了免疫细胞，包括t细胞、b细胞、巨噬细胞和树突状细胞在TME中的不同作用及其对癌症进展的影响。该综述还探讨了病毒癌蛋白如何操纵TME以促进免疫逃避和肿瘤存活。揭示这些机制凸显了靶向TME作为癌症治疗新方法的新兴范式。我们的分析提供了对病毒和TME之间动态相互作用的见解，为利用病毒性癌症独特特征的创新治疗提供了路线图。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.