Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104439

Weiwei Shi , Fang Wang , Liangliang Chen , Ruzhi Zhang

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Abstract

Background

Genital lichen sclerosus (GLS) is a chronic inflammatory skin disease affecting the genital and anal areas. Treatment of refractory remains a challenge in clinical practice.

Objective

This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for refractory GLS.

Methods

Thirty-five patients with histopathologically confirmed GLS (including 32 females and 3 males) were treated with 5-ALA PDT. Lesion pretreatment was performed to enhance photosensitizer penetration, and fluorescence diagnosis was used for precise point-to-point treatment. Efficacy and safety were systematically evaluated by assessing treatment outcomes, symptom improvement, side effects and maintenance of efficacy over a 6-month follow-up period.

Results

After treatment, most patients experienced significant relief of pruritus, improved skin elasticity and color, and reduced lesion area. After 6 treatment sessions, 11 patients (31.43 %) achieved complete resolution of pruritus, with 3 patients (8.57 %) achieving complete remission after 3 sessions. Cattaneo scores decreased significantly after treatment and during follow-up (P < 0.05). Adverse reactions were mainly mild pain, which could be relieved by ice compression or oral analgesics.

Conclusions

5-ALA PDT shows significant efficacy and good safety for refractory GLS, improving the clinical symptoms and signs of patients, and warrants wider clinical application.

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5-氨基乙酰丙酸光动力治疗难治性生殖器硬化性地衣的疗效和安全性。

背景：生殖器硬化地衣（GLS）是一种影响生殖器和肛门区域的慢性炎症性皮肤病。难治性脑炎的治疗在临床实践中仍然是一个挑战。目的：评价5-氨基乙酰丙酸光动力疗法（5-ALA PDT）治疗难治性GLS的疗效和安全性。方法：35例经组织病理学证实的GLS患者，其中女性32例，男性3例，采用5-ALA PDT治疗。病变前处理增强光敏剂穿透，荧光诊断用于精确点对点治疗。在6个月的随访期间，通过评估治疗结果、症状改善、副作用和疗效维持情况，系统地评估疗效和安全性。结果：治疗后大部分患者瘙痒症状明显缓解，皮肤弹性和颜色改善，病变面积缩小。6个疗程后，11例（31.43%）患者瘙痒症状完全缓解，3例（8.57%）患者瘙痒症状完全缓解。结论：5-ALA PDT治疗难治性GLS疗效显著，安全性好，可改善患者的临床症状和体征，值得临床推广应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.