Comparison of one-year real-world outcomes between red (670 nm) subthreshold micropulse laser treatment and intravitreal aflibercept injection for treatment-naïve diabetic macular edema

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104430

Wataru Kikushima, Yukiko Furuhata, Taiyo Shijo, Mizuki Matsumoto, Yoichi Sakurada, Daphne Viel Tsuru, Kenji Kashiwagi

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引用次数: 0

Abstract

Purpose

To evaluate the treatment outcomes of subthreshold micropulse laser (SMPL) with a wavelength of 670 nm (red) for treatment-naïve diabetic macular edema (DME).

Methods

A retrospective observational study which included 42 eyes in 34 patients diagnosed with treatment-naïve DME was conducted. Twenty-one eyes underwent red SMPL and the other 21 eyes underwent intravitreal injection of aflibercept (IVA) as initial treatment and were followed up for 12 months. Best-corrected visual acuity (BCVA), central retinal thickness (CRT) on optical coherence tomography (OCT), vessel density (VD), and foveal avascular zone area on OCT angiography (OCTA) were measured and compared between the two groups.

Results

In the red SMPL group, the mean BCVA slightly improved from 0.29 ± 0.28 at baseline to 0.22 ± 0.29 at 12 months (p = 0.18), while the mean CRT significantly decreased from 472 ± 200 µm at baseline to 320 ± 136 µm at 12 months (p = 0.003). At 12 months from baseline, the mean change in BCVA and CRT were similar between the red SMPL and IVA groups (p = 0.79 and p = 0.31, respectively). No significant change was detected in OCTA parameters except for VD at the nasal section in the red SMPL group.

Conclusion

Red SMPL for treatment-naïve DME maintained BCVA and significantly reduced CRT at 12 months. These treatment outcomes were equivalent to IVA in real-world settings, which tend to be inferior to clinical trials.

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红色（670 nm）阈下微脉冲激光治疗与玻璃体内注射阿布西普治疗Treatment-Naïve糖尿病性黄斑水肿一年真实预后的比较

目的：评价670 nm（红色）阈下微脉冲激光（SMPL）治疗treatment-naïve糖尿病性黄斑水肿（DME）的疗效。方法：回顾性观察34例treatment-naïve DME患者42只眼。21眼行红色SMPL， 21眼玻璃体内注射阿布西普（IVA）作为初始治疗，随访12个月。测量两组最佳矫正视力（BCVA）、光学相干断层扫描（OCT）视网膜中央厚度（CRT）、血管密度（VD）、OCT血管造影（OCTA）中央凹无血管区面积。结果：红色SMPL组平均BCVA从基线时的0.29±0.28略微改善到12个月时的0.22±0.29 (p=0.18)，而平均CRT从基线时的472±200µm显著降低到12个月时的320±136µm （p=0.003）。在基线后12个月，红色SMPL组和IVA组的BCVA和CRT的平均变化相似（p=0.79和p=0.31）。除红色SMPL组鼻部VD外，OCTA参数未见明显变化。结论：treatment-naïve DME的红色SMPL维持了BCVA，并显着降低了12个月的CRT。这些治疗结果与现实环境中的IVA相当，后者往往不如临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.