Mutations and MRD: clinical implications of clonal ontogeny.

IF 2.9 3区 教育学 Q1 EDUCATION, SCIENTIFIC DISCIPLINES
Jerald Radich
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引用次数: 0

Abstract

Measurable residual disease (MRD) is a strong but imprecise predictor of relapse in acute myeloid leukemia. Many patients fall into the outlier categories of MRD positivity without relapse or MRD negativity with relapse. Why? We will discuss these states in the context of "clonal ontogeny" examining how mutations, clonal structure, and Darwinian rules impact response, resistance, and relapse.

突变和MRD:克隆个体发生的临床意义。
可测量残留病(MRD)是急性髓系白血病复发的一个强有力但不精确的预测指标。许多患者属于MRD阳性无复发或MRD阴性伴复发的异常类别。为什么?我们将在“克隆个体发生”的背景下讨论这些状态,研究突变、克隆结构和达尔文规则如何影响反应、抵抗和复发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hematology. American Society of Hematology. Education Program
Hematology. American Society of Hematology. Education Program EDUCATION, SCIENTIFIC DISCIPLINES-HEMATOLOGY
CiteScore
4.70
自引率
3.30%
发文量
0
期刊介绍: Hematology, the ASH Education Program, is published annually by the American Society of Hematology (ASH) in one volume per year.
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