Resource distribution, pharmacological activity, toxicology and clinical drugs of β-Carboline alkaloids: An updated and systematic review.

Abstract

β-Carboline alkaloids are a broad class of indole alkaloids that were first isolated from Peganum harmala L., a traditional Chinese herbal remedy. β-Carboline alkaloids have been found to have many pharmacological activities, including anti-inflammatory, antioxidant, and anti-cancer properties. β-Carboline alkaloids have been studied, and nine therapeutic medications based on its structural skeleton have been utilized to treat a range of illnesses. These compounds' potent pharmacological action and high druggability have garnered a lot of interest. This review systematically summarized resource distribution, pharmacological activity, toxicology and clinical drugs of β-Carboline alkaloids. These alkaloids are mostly found in plants, particularly (Peganum harmala L.), although they are also present in food, bacteria, fungus, and animals. By inhibiting NF-κB, MAPKs, and PI3K-AKT multiple signal pathways, they demonstrate a wide range of pharmacological activities, including anti-inflammatory, oxidative, neurological, cancer, fungal, and leishmania pharmacological activity. Toxicology revealed that β-Carboline alkaloids can produce confusion, irritability, dyskinesia, nausea, vomiting, and audiovisual hallucinations in addition to stimulating the central nervous system and inhibiting metabolism. Clinical drugs based on β-Carboline alkaloids have been used for clinical treatment of arrhythmia, cerebrovascular diseases and dysfunction, hypertension, epilepsy, malaria and mydriasis diseases. It will prompt us to redefine β-Carboline alkaloids. For β-Carboline alkaloids that inspires pharmacological applications in medicine and the development of novel medications containing these alkaloids, it will be a useful resource.