TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond.

IF 7.7 2区 医学 Q1 ONCOLOGY
Qitong Wu, Deeptashree Nandi, Dipali Sharma
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引用次数: 0

Abstract

While most Tripartite motif (TRIM) family proteins are E3 ubiquitin ligases, some members have functions beyond the regulation of ubiquitination, impacting normal physiological processes and disease progression. TRIM29, an important member of the TRIM family, exerts a predominant influence on cancer growth, epithelial-to-mesenchymal transition, stemness and metastatic progression by directly potentiating multiple canonical oncogenic pathways. The cancer-promoting effect of TRIM29 is also evident in metabolic interventions and interference with the efficacy of cancer therapeutics. As expected for any key node in cancer, the expression of TRIM29 is tightly regulated by non-coding RNAs, epigenetic modulation, and post-translational regulation. A systematic discussion of how TRIM29 is regulated in cancer, its influences on cancer progression, and its impact on cancer therapeutics is presented in this review. We also explore the context-dependent alterations between TRIM29 function from oncogenic to tumor suppression. As TRIM29 is involved in multiple aspects of cancer progression, a better understanding of its biological impact in cancer may help improve prognosis and develop novel therapeutic combinations, leading to improved personalized cancer care.

trim3 - motif 29 (TRIM29)在癌症进展及其后的内源功能网络。
虽然大多数TRIM家族蛋白是E3泛素连接酶,但一些成员的功能超出了泛素化的调节,影响正常的生理过程和疾病进展。TRIM29是TRIM家族的重要成员,通过直接增强多种典型的致癌途径,对肿瘤生长、上皮-间质转化、干性和转移进展发挥重要影响。TRIM29的促癌作用在代谢干预和干扰癌症治疗药物的疗效方面也很明显。正如预期的那样,TRIM29的表达受到非编码rna、表观遗传调控和翻译后调控的严格调控。本文系统地讨论了TRIM29在癌症中的调控机制、对癌症进展的影响以及对癌症治疗的影响。我们还探讨了TRIM29功能从致癌到肿瘤抑制之间的环境依赖性改变。由于TRIM29参与癌症进展的多个方面,更好地了解其在癌症中的生物学影响可能有助于改善预后和开发新的治疗组合,从而改善个性化的癌症治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
17.00
自引率
0.00%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
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