Gargantuan carcinoma ex-pleomorphic adenoma of the submandibular gland: Case report and review of literature

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-01-01 DOI:10.1016/j.amjoto.2024.104539

Milena Fabry , Jamie Shehan , Jacob Markovicz , Mohamedkazim Alwani MD , Sameep Kadakia

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引用次数: 0

Abstract

Introduction

Pleomorphic adenoma is the most common neoplasm of the major salivary glands, and can undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA) in untreated patients.

Case presentation

Our case describes a 56-year-old male with a 15-year history of slowly growing expansive right-sided neck. He underwent excision of the neck mass, neck dissection, and pectoralis flap reconstruction. Final pathology revealed a 22 cm CXPA with myoepithelial and salivary duct carcinoma components. The patient was recommended radiation therapy to receive 66 Gy in 33 fractions.

Discussion

CXPA is rare, typically aggressive, and carries a poor prognosis. This case is unique given the location of the tumor arising from the submandibular gland and delayed presentation leading to its massive size. Surgical planning for a lesion of this nature is complex due to structures in the vicinity and additional needs for reconstruction. Another important consideration highlighted by this case includes the need to assess patient reliability and provide resources to reduce the odds of being lost to follow up and enhance patient care.

查看原文本刊更多论文

颌下腺巨癌前多形性腺瘤一例报告及文献复习。

简介：多形性腺瘤是主要唾液腺最常见的肿瘤，未经治疗的患者可恶性转化为癌前多形性腺瘤（CXPA）。病例介绍：我们的病例描述了一个56岁的男性，15年的历史缓慢增长扩张的右侧颈部。他接受了颈部肿块切除、颈部剥离和胸肌瓣重建。最终病理显示一个22厘米的CXPA，含有肌上皮和唾液管癌成分。建议患者接受33次66 Gy的放射治疗。讨论：肺外炎罕见，典型侵袭性，预后较差。这个病例是独特的，因为肿瘤起源于下颌骨腺和延迟的表现导致其巨大的大小。由于附近的结构和重建的额外需求，这种性质的病变的手术计划是复杂的。本病例强调的另一个重要考虑因素包括需要评估患者的可靠性，并提供资源以减少失去随访和加强患者护理的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.