[The Role of the Left Atrium in the Pathogenesis of Heart Failure With Preserved Ejection Fraction].

IF 0.5 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
A G Ovchinnikov, A V Potekhina, A Yu Filatova, O N Svirida, M Kh Shogenova, M S Sobolevskaya, F T Ageev
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引用次数: 0

Abstract

Left atrial dysfunction (left atrial myopathy) is not only a consequence of impaired left ventricular diastolic function but also plays a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left atrial myopathy in HFpEF is associated with a more severe course of heart failure and an unfavorable prognosis, and the choice of treatment largely depends on its severity. Echocardiography allows an accurate assessment of the left atrial condition, while the parameters of left atrial myocardial strain are sensitive to early functional disorders to help diagnosing HFpEF and determining the prognosis. This article discusses the participation of the left atrium in the left ventricular filling, its status at different stages of left ventricular diastolic dysfunction, the major mechanisms of atrial myopathy in HFpEF, and therapeutic approaches to its restriction and reversion.

左心房在保留射血分数的心力衰竭发病机制中的作用。
左房功能障碍(左房肌病)不仅是左室舒张功能受损的结果,而且在保留射血分数(HFpEF)心力衰竭的病理生理中起着核心作用。HFpEF的左房肌病与更严重的心衰病程和不良预后相关,治疗的选择在很大程度上取决于其严重程度。超声心动图可以准确评估左房状况,而左房心肌应变参数对早期功能障碍敏感,有助于诊断HFpEF并确定预后。本文讨论左心房在左室充盈中的作用,左心房在左室舒张功能不全不同阶段的地位,HFpEF中心房肌病的主要机制,以及限制和逆转心房肌病的治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Kardiologiya
Kardiologiya 医学-心血管系统
CiteScore
1.70
自引率
20.00%
发文量
94
审稿时长
3-8 weeks
期刊介绍: “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.
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