Functional gold nanoparticles for analysis and delivery of nucleic acids.

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI:10.38212/2224-6614.3514

Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang

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引用次数: 0

Abstract

Gold nanoparticles (AuNPs) have become the rising stars in the field of nanotechnology and made a revolution in exploiting the profundity of genomics due to their distinguished properties such as stability, ease in preparation and conjugation, biocompatibility, and unique optical properties. These characteristics have greatly expanded their applications such as sensitive and selective quantitation of nucleic acids and as effective carriers for specifically delivering various important molecules/biomolecules to various targets, which are the cornerstone in treating genetic disorders. This review comprehensively discusses the most recent progress in utilization of AuNPs in quantitation and delivery of nucleic acids. The future prospects and challenges of various methods have also been illustrated. It is believed that researchers will continue to overcome the limitations in previous approaches and AuNPs will still play vital roles in the development of diagnosis and treatment of gene-related diseases.

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用于核酸分析和递送的功能性金纳米颗粒。

金纳米粒子（AuNPs）由于其稳定性、易于制备和偶联、生物相容性和独特的光学特性等特点，已成为纳米技术领域的新星，并在深入开发基因组学方面进行了一场革命。这些特性极大地扩展了其应用范围，如核酸的敏感和选择性定量，以及作为特异性递送各种重要分子/生物分子到各种靶点的有效载体，是治疗遗传疾病的基石。本文综述了利用AuNPs进行核酸定量和传递的最新进展。并对各种方法的发展前景和面临的挑战进行了说明。相信研究人员将继续克服以往方法的局限性，aunp仍将在基因相关疾病的诊断和治疗发展中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Food and Drug Analysis 医学-食品科技

CiteScore

6.30

自引率

2.80%

发文量

审稿时长

3.8 months

期刊介绍： The journal aims to provide an international platform for scientists, researchers and academicians to promote, share and discuss new findings, current issues, and developments in the different areas of food and drug analysis. The scope of the Journal includes analytical methodologies and biological activities in relation to food, drugs, cosmetics and traditional Chinese medicine, as well as related disciplines of topical interest to public health professionals.