Leveraging zebrafish models for advancing radiobiology: Mechanisms, applications, and future prospects in radiation exposure research.

IF 7.7 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ting Xu, Fan Liu, Jiaxuan He, Peiye Xu, Junying Qu, Hanbing Wang, Jinghui Yue, Qinsi Yang, Wei Wu, Guoming Zeng, Da Sun, Xia Chen
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引用次数: 0

Abstract

Ionizing radiation (IR) represents a significant risk to human health and societal stability. To effectively analyze the mechanisms of IR and enhance protective strategies, the development of more sophisticated animal models is imperative. The zebrafish, with its high degree of genomic homology to humans and the capacity for whole-body optical visualization and high-throughput screening, represents an invaluable model for the study of IR. This review examines the benefits of utilizing zebrafish as a model organism for research on IR, emphasizing recent advancements and applications. It presents a comprehensive overview of the methodologies for establishing IR models in zebrafish, addresses current challenges, and discusses future development trends. This paper provide theoretical support for elucidating the mechanisms of IR injury and developing effective treatment strategies.

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来源期刊
Environmental Research
Environmental Research 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
12.60
自引率
8.40%
发文量
2480
审稿时长
4.7 months
期刊介绍: The Environmental Research journal presents a broad range of interdisciplinary research, focused on addressing worldwide environmental concerns and featuring innovative findings. Our publication strives to explore relevant anthropogenic issues across various environmental sectors, showcasing practical applications in real-life settings.
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