Novel Use of Manganese Gluconate as a Marker for Visualization of Tablet Dissolution in the Fed Human Stomach Using Magnetic Resonance Imaging.

IF 4.5 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular Pharmaceutics Pub Date : 2025-01-06 Epub Date: 2024-12-05 DOI:10.1021/acs.molpharmaceut.4c00854

Tejal Akbar, Pavel Gershkovich, Konstantinos Stamatopoulos, Penny A Gowland, Snow Stolnik, James Butler, Luca Marciani

引用次数: 0

Abstract

Magnetic resonance imaging (MRI) of dry or solid materials in the gastrointestinal (GI) tract requires the use of contrast agents to enhance visualization of the dosage forms. In this study, we explore the novel use of manganese gluconate added to tablets. Manganese was released during tablet dissolution, generating a bright "halo" effect around the tablets, consistent with shortening of the longitudinal relaxation time of the bulk water surrounding the tablet. This is the first study to use MRI to directly image tablet dissolution in the fed stomach using a manganese gluconate contrast agent as dissolution marker.

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葡萄糖酸锰作为一种新的标记物，应用磁共振成像技术可视化片剂在胃中的溶出度。

磁共振成像（MRI）干燥或固体物质在胃肠道（GI）需要使用造影剂，以增强可视化的剂型。在这项研究中，我们探索了葡萄糖酸锰添加到片剂中的新用途。锰在片剂溶解过程中被释放，在片剂周围产生明亮的“晕”效应，与片剂周围散装水纵向松弛时间的缩短一致。这是第一次使用核磁共振成像直接成像片剂在胃里的溶解，使用葡萄糖酸锰造影剂作为溶解标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Pharmaceutics 医学-药学

CiteScore

8.00

自引率

6.10%

发文量

391

审稿时长

2 months

期刊介绍： Molecular Pharmaceutics publishes the results of original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. The journal encourages contributions describing research at the interface of drug discovery and drug development. Scientific areas within the scope of the journal include physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science as they relate to drug and drug delivery system efficacy. Mechanistic Drug Delivery and Drug Targeting research on modulating activity and efficacy of a drug or drug product is within the scope of Molecular Pharmaceutics. Theoretical and experimental peer-reviewed research articles, communications, reviews, and perspectives are welcomed.