Infiltration of micro-fragmented adipose tissue under local anesthesia for knee osteoarthritis treatment is a safe procedure: A case series.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI:10.1016/j.clinsp.2024.100527

Bruno Butturi Varone, Daniel Peixoto Leal, Daniel Duarte Perini, Vitor Penteado Figueiredo Pagotto, Riccardo Gomes Gobbi, Marco Kawwamura Demange

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引用次数: 0

Abstract

Introduction: Knee osteoarthritis is a debilitating disease that has been increasing in prevalence, especially due to the aging population and rising incidence of obesity. Biological therapies (orthobiologics) have emerged, demonstrating efficacy in improving functional scores, including the injection of microfragmented Adipose Tissue (mFAT). The purpose of this study is to evaluate the safety of adipose tissue harvesting and mFAT injection under local anesthesia.

Materials/methods: A case series involving 34 patients who underwent adipose tissue collection from the abdomen under local anesthesia, without sedation, in a sterile environment, and who received the infiltration of microfragmented adipose tissue after single-time preparation, using a fat washing and microfragmentation kit.

Results: Evaluation was performed at the time of the procedure and after 7 days of follow-up. Only ecchymosis (76.5 %) and mild discomfort at the harvested site (70.6 %), as well as mild discomfort at the infiltrated knee (61.8 %), were identified. No major adverse events were identified.

Conclusion: The harvesting and injection of mFAT under local anesthesia is safe, with no major adverse events identified during this procedure.

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局部麻醉下微碎片脂肪组织浸润治疗膝骨关节炎是一种安全的方法：一个病例系列。

导读：膝关节骨性关节炎是一种使人衰弱的疾病，其发病率一直在上升，特别是由于人口老龄化和肥胖发病率的上升。生物疗法（orthobiologics）已经出现，显示出改善功能评分的有效性，包括注射微碎片脂肪组织（microfragmentation Adipose Tissue, mFAT）。本研究的目的是评估局麻下脂肪组织采集和mFAT注射的安全性。材料/方法：34例患者在局部麻醉下，不使用镇静，无菌环境下从腹部收集脂肪组织，使用脂肪洗涤和微碎片化试剂盒，一次性制备后进行微碎片化脂肪组织浸润。结果：在手术时和随访7天后进行评估。仅发现瘀斑（76.5%）和收获部位轻度不适（70.6%），以及浸润膝关节轻度不适（61.8%）。未发现重大不良事件。结论：局麻下mFAT的采集和注射是安全的，在此过程中未发现重大不良事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.