Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies.

IF 3.9 3区医学 Q1 PSYCHIATRY

BJPsych Open Pub Date : 2024-12-05 DOI:10.1192/bjo.2024.766

Gemma Greenfinch, Calum A Hamilton, Paul C Donaghy, Michael Firbank, Nicola A Barnett, Louise Allan, George S Petrides, John-Paul Taylor, John T O'Brien, Alan J Thomas

引用次数: 0

Abstract

The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was -5.2% (range: -23.8% to +7.0%). The interpolated mean annual change in uptake was -1.6%.

查看原文本刊更多论文

路易体轻度认知障碍患者心脏mIBG闪烁图的纵向变化。

本研究的目的是确定基线扫描正常的轻度认知障碍伴路易体（MCI-LB）患者的心脏[123I]-甲氧苄基胍摄取在基线和随访期间是否有显著变化。8名诊断为可能MCI-LB且基线扫描正常的参与者同意在基线后2至4年内进行随访扫描。8次重复扫描均正常；然而，在三个病例中，摄取量下降超过10%。基线和重复之间摄取的平均变化为-5.2%（范围：-23.8%至+7.0%）。内插的年平均吸收变化为-1.6%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BJPsych Open Medicine-Psychiatry and Mental Health

CiteScore

6.30

自引率

3.70%

发文量

610

审稿时长

16 weeks

期刊介绍： Announcing the launch of BJPsych Open, an exciting new open access online journal for the publication of all methodologically sound research in all fields of psychiatry and disciplines related to mental health. BJPsych Open will maintain the highest scientific, peer review, and ethical standards of the BJPsych, ensure rapid publication for authors whilst sharing research with no cost to the reader in the spirit of maximising dissemination and public engagement. Cascade submission from BJPsych to BJPsych Open is a new option for authors whose first priority is rapid online publication with the prestigious BJPsych brand. Authors will also retain copyright to their works under a creative commons license.