Hydrocarbon chains of biomembrane phospholipids: structural realizations of noncrystallographic symmetrical constructions

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-12-06 DOI:10.1007/s11172-024-4425-1

A. L. Talis

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Abstract

The characteristic features of the structures of the most common hydrocarbon (fatty acid) chains of phospholipid molecules that form the basis for biological membranes are considered. It has been established that the most symmetrical association of tetrahedrally coordinated chains corresponding to the hydrocarbon chains of phospholipids was found to be the four-dimensional 240-vertex diamond-like substructure of a three-dimensional sphere: the {240} polytope. The building blocks of the phospholipid hydrocarbon chain are defined as 14- and 11-vertex fragments of the tetrahedrally coordinated linear substructure of the {240} polytope and are also defined by structural realizations of a special combinatorial construction on seven symbols. It is shown that the symmetry-based requirement for the assembly only from an integer number of such building blocks makes it possible to explain the realization of a very limited number of hydrocarbon chains of biomembrane phospholipids from a huge number of combinatorially possible variants of similar chains.

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生物膜磷脂的碳氢化合物链：非晶体对称结构的结构实现

最常见的碳氢化合物（脂肪酸）链磷脂分子的结构的特征，形成生物膜的基础被考虑。已经确定，与磷脂的烃链相对应的四面体配位链的最对称的组合是三维球体的四维240顶点类金刚石亚结构：{240}多面体。磷脂烃链的构建块被定义为{240}多面体的四面体协调线性亚结构的14和11顶点片段，也被定义为七个符号的特殊组合结构的结构实现。研究表明，基于对称性的组装要求仅来自整数个这样的构建块，这使得有可能解释从大量相似链的组合可能变体中实现非常有限数量的生物膜磷脂的碳氢化合物链。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.