{"title":"Silent silencers: Leave no trace","authors":"Dogancan Ozturan, Carl G. de Boer","doi":"10.1016/j.molcel.2024.11.005","DOIUrl":null,"url":null,"abstract":"The regulatory mechanisms of silencers have remained poorly understood. In this issue, Hofbauer et al.<span><span><sup>1</sup></span></span> conduct a genome-wide screen in <em>Drosophila melanogaster</em> and reveal three silencer types that appear to work alone—without the need for combinatorial action, traditional chromatin marks, or open chromatin regions.","PeriodicalId":18950,"journal":{"name":"Molecular Cell","volume":"12 1","pages":""},"PeriodicalIF":14.5000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.molcel.2024.11.005","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The regulatory mechanisms of silencers have remained poorly understood. In this issue, Hofbauer et al.1 conduct a genome-wide screen in Drosophila melanogaster and reveal three silencer types that appear to work alone—without the need for combinatorial action, traditional chromatin marks, or open chromatin regions.
期刊介绍:
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.