From brain to blood and back again: Linking chronic stress, myelopoiesis, and depression

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-12-05 DOI:10.1016/j.stem.2024.11.012

Ioanna Mosialou, Stavroula Kousteni

引用次数: 0

Abstract

In this issue of Cell Stem Cell, Mou et al. identified a brain-bone marrow axis reinforcing myelopoiesis and neuroinflammation during psychological stress, culminating in depression. The identification of this pathway provides insights into hematopoietic stem cell homeostasis and regulatory neuronal function with potentially significant implications for the treatment of stress-related disorders.

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从大脑到血液再回来：连接慢性压力，骨髓生成和抑郁症

在这一期的Cell Stem Cell中，Mou等人发现了脑-骨髓轴在心理应激期间加强骨髓生成和神经炎症，最终导致抑郁。这一途径的发现提供了对造血干细胞稳态和调节神经元功能的深入了解，对治疗应激相关疾病具有潜在的重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.