[Allergic bronchopulmonary aspergillosis in a patient with diabetes mellitus as the only risk factor].

Alejandro Hernández-Solís, Guillermo Velázquez-Sámano, Verónica Apolinar-Juárez, Eliasib Mojica Jaimes, Fryda Jareth Serna Valle, Yutzil Merari Velazquez Gachuz
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Abstract

Background: Allergic bronchopulmonary aspergillosis is a rare entity, caused by a hypersensitivity reaction of the immune system to Aspergillus fumigatus, characterized by the presence of pulmonary infiltrates, bronchiectasis and increased eosinophils in peripheral blood.

Case report: 42-year-old male with diabetes mellitus, with poor adherence to treatment, went to the emergency room due to rapidly progressive dyspnea and severe hypoxemia, pneumonia and bilateral pleural effusion were evident, laboratory studies reported, HbA1c 9.4%, eosinophils 3650 cells/mL, serum IgE for Aspergillus fumigatus 0.84 IU/mL. Treatment was started with supplemental oxygen, prednisone and itraconazole, to which the patient showed clinical and radiological improvement.

Conclusions: Invasive mycoses have a mortality of 21 to 80%, frequently in immunocompromised patients, they are usually not described in patients with diabetes mellitus; The prevalence of fungal colonization among diabetic patients has been described as 37% compared to 4.7% in non-diabetic patients.

[糖尿病为唯一危险因素的变应性支气管肺曲菌病]。
背景:过敏性支气管肺曲霉病是一种罕见的疾病,由免疫系统对烟曲霉的超敏反应引起,以肺部浸润、支气管扩张和外周血嗜酸性粒细胞增加为特征。病例报告:42岁男性,糖尿病患者,治疗依从性差,因快速进行性呼吸困难,严重低氧血症,肺炎,双侧胸腔积液明显,实验室检查报告,HbA1c 9.4%,嗜酸性粒细胞3650细胞/mL,血清烟曲霉菌IgE 0.84 IU/mL。治疗开始时给予补氧、强的松和伊曲康唑治疗,患者临床和放射学均有改善。结论:侵袭性真菌病的死亡率为21% ~ 80%,常见于免疫功能低下的患者,通常不见于糖尿病患者;糖尿病患者的真菌定植率为37%,而非糖尿病患者的真菌定植率为4.7%。
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