Mechanism of ferroptosis resistance in cancer cells.

IF 4.6 Q1 ONCOLOGY
癌症耐药(英文) Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI:10.20517/cdr.2024.127
Yuan Wang, Guifang Yu, Xin Chen
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引用次数: 0

Abstract

Ferroptosis is an iron-dependent cell death characterized by increased intracellular lipid peroxidation. Inducing ferroptosis has shown significant potential in eliminating various malignancies. However, the effectiveness of ferroptosis-based treatments is hampered by the intrinsic or acquired resistance of some tumors. In this review, we delineate the known mechanisms that regulate ferroptosis sensitivity and summarize the therapeutic application of ferroptosis inducers in cancer. Additionally, we discuss the roles of diverse signaling pathways that contribute to ferroptosis resistance in cancer cells, including the glutathione (GSH) and coenzyme Q (CoQ) pathways, NFE2-like bZIP transcription factor 2 (NRF2) antioxidant response, and lipid and iron metabolism. This emerging knowledge may serve as a foundation for developing novel anticancer strategies to overcome ferroptosis resistance.

癌细胞抗铁下垂机制的研究。
铁下垂是一种铁依赖性细胞死亡,其特征是细胞内脂质过氧化增加。诱导铁下垂在消除各种恶性肿瘤方面显示出显著的潜力。然而,一些肿瘤的固有或获得性耐药阻碍了基于铁中毒的治疗的有效性。在这篇综述中,我们描述了已知的调节铁下垂敏感性的机制,并总结了铁下垂诱导剂在癌症中的治疗应用。此外,我们还讨论了多种信号通路的作用,包括谷胱甘肽(GSH)和辅酶Q (CoQ)途径,nfe2样bZIP转录因子2 (NRF2)抗氧化反应,以及脂质和铁代谢。这一新兴的知识可以作为开发新的抗癌策略来克服铁下垂抵抗的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
0.00%
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