Computational neuroscience as a tool for studying neurons.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_120

Michal Sabo, Martin Kopani

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引用次数: 0

Abstract

Objectives: Computational neuroscience uses a neuron model to investigate the behavior of a neuron under different stimuli e.g. magnetic field. The aim of the study is to investigate the effect of conductivity change of sodium (Na+) and potassium (K+) ion channels on the generation and course of action potential, excitability and firing rate of neuron.

Methods: HHSim (Hodgkin-Huxley) graphical simulator was used for investigation of generation and firing rate of action potential (AP) and investigation of neuronal excitability.

Results: Na+ channel downregulation of conductance reveals a decrease of AP amplitude, and upregulation an increase of amplitude. Higher conductance of Na+ channel leads to higher firing rate from the value 53 HZ to 66 Hz. K+ channel downregulation of conductance reveals an increase of AP amplitude. Lower conductance of K+ channel leads to higher firing rate from the value 62 HZ to 68 Hz. K+ channel upregulation of conductance shows a decrease of AP amplitude.

Conclusion: From the results it can be drawn that effect of conductivity change as a result of magnetic field is significant and can leads to change of neurons. uman brain cultures, often termed "glia-like" cells (Tab. 4, Fig. 6, Ref. 21).

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计算神经科学作为研究神经元的工具。

目的：计算神经科学使用神经元模型来研究神经元在不同刺激（如磁场）下的行为。本研究旨在探讨钠离子通道和钾离子通道电导率的变化对动作电位的产生和过程、神经元的兴奋性和放电速率的影响。方法：采用HHSim （Hodgkin-Huxley）图形模拟器研究动作电位（AP）的产生和放电速率以及神经元的兴奋性。结果：Na+通道电导下调表现为AP幅值降低，上调表现为AP幅值升高。在53 ~ 66 HZ范围内，Na+通道电导越高，放电速率越高。K+通道电导下调显示AP振幅增加。较低的K+通道电导导致较高的发射速率，从62 HZ到68 HZ。K+通道电导的上调表现为AP振幅的降低。结论：从结果可以看出，磁场对大鼠电导率的影响是显著的，并可导致神经元的改变。人脑培养物，通常被称为“胶质样”细胞（表4，图6，参考文献21）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bratislava Medical Journal-Bratislavske Lekarske Listy 医学-医学：内科

CiteScore

2.60

自引率

0.00%

发文量

185

审稿时长

3-8 weeks

期刊介绍： The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.