Impact of asthma severity on surgical outcomes in patients with chronic rhinosinusitis comorbid with asthma

IF 4.7 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI:10.1016/j.anai.2024.11.022

Bo Zhang MD , Min Yan MD , Cong Li MD , Jiashu Zhao MD , Yang Liu MD , Xiaomei Yang MD , Xuelan Zeng MD , Zhiying Nie MD , Zhaoyang Ke MD , Wei Zhang MD , Yuanyuan Guo MD , Jianbo Shi MD, PhD , Fenghong Chen MD

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引用次数: 0

Abstract

Background

Patients with chronic rhinosinusitis with nasal polyps comorbid with asthma often experience poor outcomes after endoscopic sinus surgery.

Objective

To evaluate the impact of asthma severity on the long-term outcomes after surgery in these patients.

Methods

A total of 83 patients with chronic rhinosinusitis with nasal polyps comorbid with asthma who underwent endoscopic sinus surgery were prospectively enrolled in this study. Patients were classified into mild, moderate, and severe asthma groups based on their preoperative asthma severity. Clinical symptom scores, nasal endoscopy scores, and asthma control test results were recorded preoperatively and at 1 year and 12 years postoperatively.

Results

A total of 71 patients completed the 12-year follow-up. All patients had significant improvement in nasal symptom scores and nasal endoscopy scores. However, 48 of 71 patients (67.6%) experienced nasal polyp recurrence, and 22 of them (31.0%) underwent revision surgery. Patients in the severe asthma group had the highest rate of nasal polyp recurrence (P = .02) and revision surgery (P = .01) and the least improvement in smell disturbance (P = .04) and general symptom (P = .02) compared with the other asthma groups.

Conclusion

Preoperative asthma severity significantly influenced the outcome of endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps comorbid with asthma, in whom endoscopic sinus surgery had a long-term beneficial effect.

Trial Registration

https://www.chictr.org.cn/: ChiCTR2100050583.

查看原文本刊更多论文

哮喘严重程度对慢性鼻窦炎合并哮喘患者手术结果的影响。

背景：慢性鼻窦炎合并鼻息肉并哮喘的患者在鼻窦内窥镜手术后往往预后不佳。目的：本研究旨在评估哮喘严重程度对这些患者术后长期预后的影响。方法：83例慢性鼻窦炎合并鼻息肉合并哮喘患者行鼻内窥镜手术，前瞻性纳入本研究。根据患者术前哮喘严重程度将患者分为轻度、中度和重度哮喘组。术前、术后1年、12年分别记录临床症状评分、鼻内窥镜评分和哮喘控制试验结果。结果：71例患者完成了12年的随访。所有患者的鼻症状评分和鼻内窥镜评分均有显著改善。然而，71例患者中有48例（67.6%）鼻息肉复发，其中22例（31.0%）行鼻息肉翻修手术。重度哮喘组鼻息肉复发率最高（P=0.02），翻修手术率最高（P=0.01），嗅觉障碍改善率最低（P=0.04），一般症状改善率最低（P=0.02）。结论：慢性鼻窦炎合并鼻息肉合并哮喘患者术前哮喘严重程度显著影响鼻内镜手术的预后，鼻内镜手术具有长期的有益效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.