Patient Blood Management in pediatric and adolescent bone marrow donors: results from an Italian survey.

IF 2.4 3区 医学 Q2 HEMATOLOGY
Claudia Del Fante, Francesca Masiello, Marco Zecca, Ursula La Rocca, Simonetta Pupella, Vincenzo De Angelis
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引用次数: 0

Abstract

Background: Current national and international guidelines (Italian Bone Marrow Donor Registry [IBMDR], World Marrow Donor Association [WMDA] standards) provide an indication for preoperative autologous blood donation (PAD) only in adult family and volunteer non-family donors in anticipation of bone marrow (BM) hematopoietic stem cell (HSC) donation to avoid the use of homologous transfusions. In addition, there is no clear guidance from the relevant scientific societies regarding pediatric and adolescent donors.

Material and methods: To assess the actual use of PAD in pediatric (up to 14 years) and adolescent (aged 15-18 years) family donors in relation to BM HSC donation in the five years 2017-2021, a specific online questionnaire was administered to blood establishments and clinical units of pediatric transplantation programs responsible for BM HSC collection.

Results: Adherence to the project was 100% (18/18 centers). During the five-year period considered, 273 BM HSC donors (205 pediatric and 68 adolescent) were registered. Forty percent of the non-trait carrier donors who underwent PAD received iron therapy in preparation for BM HSC donation; only 4.8% of the pediatric and none of the adolescents had hemoglobin values below the age limit at donation. Finally, 66.4% of pediatric donors and 15.4% of non-trait carrier adolescent donors who did not undergo PAD received homologous transfusions during BM harvest.

Discussion: The present study highlights the highly heterogeneous criteria for the use of PAD (including calculating of the volume of whole blood collected) and the lack of a specific policy in preparation for BM HSC donation, either from non-trait carrier donors or those with sickle cell or thalassemia trait, both pediatric and adolescent.

儿童和青少年骨髓献血者的患者血液管理:来自意大利一项调查的结果。
背景:目前的国家和国际指南(意大利骨髓捐献登记[IBMDR],世界骨髓捐献协会[WMDA]标准)提供了术前自体献血(PAD)的指征,仅适用于成年家庭和志愿非家庭献血者,预期骨髓(BM)造血干细胞(HSC)捐献,以避免使用同源输血。此外,相关科学学会对儿童和青少年献血者没有明确的指导。材料和方法:为了评估2017-2021年五年间PAD在儿科(14岁以下)和青少年(15-18岁)家庭献血者中与BM HSC捐赠相关的实际使用情况,对负责BM HSC收集的儿科移植项目的血液机构和临床单位进行了一份特定的在线问卷调查。结果:项目依从性为100%(18/18个中心)。在考虑的5年期间,登记了273名BM HSC捐赠者(205名儿童和68名青少年)。接受PAD的非性状携带者供者中,有40%接受了铁治疗,为BM HSC捐献做准备;只有4.8%的儿童和青少年的血红蛋白值在捐献时低于年龄限制。最后,66.4%的儿童献血者和15.4%的未接受PAD的非特征携带者青少年献血者在BM收获期间接受了同源输血。讨论:目前的研究强调了PAD使用的高度异质性标准(包括计算收集的全血量),以及在准备BM HSC捐赠时缺乏具体的政策,无论是来自非性状携带者供者还是患有镰状细胞或地中海贫血性状的供者,无论是儿童还是青少年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Blood Transfusion
Blood Transfusion HEMATOLOGY-
CiteScore
6.10
自引率
2.70%
发文量
91
审稿时长
2 months
期刊介绍: Blood Transfusion welcomes international submissions of Original Articles, Review Articles, Case Reports and Letters on all the fields related to Transfusion Medicine.
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