Sex Differences in the Prevalence of Geriatric Syndromes Among Older People Living with HIV Attending an Urban Outpatient Clinic in Kampala, Uganda.

IF 1.5 Q4 INFECTIOUS DISEASES

HIV AIDS-Research and Palliative Care Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI:10.2147/HIV.S489598

Phoebe Mbabazi, Grace Banturaki, Suzan Naikoba, Esther M Nasuuna, Yukari C Manabe, Meredith Greene, Barbara Castelnuovo

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Abstract

Background: Older people living with HIV (PLHIV) are at high risk of developing geriatric syndromes. Data on geriatric syndromes among older PLHIV in sub-Saharan Africa are scarce. We examined sex differences in the prevalence and correlates of geriatric syndromes among PLHIV aged ≥60 years on antiretroviral therapy in Kampala, Uganda.

Methods: This cross-sectional study analyzed data obtained during the enrollment of older PLHIV into a prospective observational cohort in Kampala. We used the Poisson regression model to explore the association between the number of geriatric syndromes and non-communicable diseases (NCDs), sociodemographic factors, and HIV-related factors.

Results: We included 500 participants (48.8% women) with a median age of 64 years (interquartile range, IQR: 62.68). Almost all (94.4%) participants had at least one geriatric syndrome. More women were frail (13.1% vs 5.1%, P-value = 0.01) and had lower physical performance measured using the Short Physical Performance Battery (43.3% vs 26.6%, P-value < 0.01). Similarly, more women had cognitive impairment (83.2% vs 62.9%, P-value < 0.01) and reported falling (48.8% vs 34.0%, P-value < 0.01). Women (adjusted mean ratio, AMR 1.17, 95% CI 1.05-1.30, P-value < 0.01), older age (AMR 1.11, 95% CI 1.07-1.16, P-value < 0.01), no formal education (AMR 1.39, 95% CI 1.06-1.82, P-value = 0.01), underweight (AMR 1.49, 95% CI 1.26-1.76, P-value < 0.01), World Health Organization (WHO) stage 3 or 4 (AMR 1.11, 95% CI 0.01-1.22, P-value = 0.04) and having two or more NCDs (AMR 1.11, 95% CI 1.00-1.23, P-value = 0.04) were associated with a higher number of geriatric syndromes.

Conclusion: The prevalence of geriatric syndromes was high among older PLHIV and was more common in women. There is a need to incorporate the screening and management of geriatric syndromes into the care of older PLHIV in sub-Saharan Africa, with a particular focus on women.

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乌干达坎帕拉城市门诊的老年艾滋病毒感染者中老年综合征患病率的性别差异

背景：老年人感染艾滋病毒（PLHIV）是发生老年综合征的高危人群。撒哈拉以南非洲地区老年艾滋病毒感染者的老年综合征数据很少。我们研究了乌干达坎帕拉接受抗逆转录病毒治疗的年龄≥60岁的PLHIV患者中患病率和老年综合征相关因素的性别差异。方法：这项横断面研究分析了坎帕拉一项前瞻性观察队列中老年PLHIV患者入组时获得的数据。我们使用泊松回归模型来探讨老年综合征数量与非传染性疾病（NCDs）、社会人口因素和hiv相关因素之间的关系。结果：我们纳入了500名参与者（48.8%为女性），中位年龄为64岁（四分位数间距，IQR: 62.68）。几乎所有（94.4%）的参与者至少有一种老年综合征。更多的女性身体虚弱（13.1% vs 5.1%， p值= 0.01），使用短体能电池测量的身体表现较差（43.3% vs 26.6%， p值< 0.01）。同样，更多的女性出现认知障碍（83.2% vs 62.9%， p值< 0.01）和下降（48.8% vs 34.0%， p值< 0.01）。女性(调整比例,AMR 1.17, 95%可信区间1.05 - -1.30,p < 0.01),老年(AMR 1.11, 95%可信区间1.07 - -1.16,p < 0.01),没有正规教育(AMR 1.39, 95%可信区间1.06 - -1.82,p = 0.01),体重不足(AMR 1.49, 95%可信区间1.26 - -1.76,p < 0.01),世界卫生组织(世卫组织)3期或4期(AMR 1.11, 95%可信区间0.01 - -1.22,p = 0.04),两个或两个以上的非传染性疾病(AMR 1.11, 95%可信区间1.00 - -1.23,p值= 0.04)与更多的老年综合症有关。结论：老年PLHIV感染者中老年综合征患病率较高，且以女性多见。有必要将老年综合征的筛查和管理纳入撒哈拉以南非洲老年艾滋病毒感染者的护理中，并特别关注妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HIV AIDS-Research and Palliative Care INFECTIOUS DISEASES-

CiteScore

3.00

自引率

6.70%

发文量

审稿时长

16 weeks

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