[Progress of researches on toxoplasmosis vaccines based on the CRISPR/Cas9 technology].

Q3 Medicine

中国血吸虫病防治杂志 Pub Date : 2024-09-20 DOI:10.16250/j.32.1374.2024026

Y Wu, X Zhang, J Li, J Xie, L Wang, H Sun

引用次数: 0

Abstract

Toxoplasma gondii is an obligatory intracellular parasite which infects a variety of warm-blooded animals and causes toxoplasmosis. Toxoplasmosis seriously endangers human health and animal husbandry production. As one of the effective gene editing tools, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) system has been widely used for knockout of genes in T. gondii. This review summarizes the applications of the CRISPR/Cas9 technology in vaccines against single- and double-gene deletion strains of T. gondii, so as to provide insights into development of toxoplasmosis vaccines.

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[基于CRISPR/Cas9技术的弓形虫病疫苗研究进展]。

刚地弓形虫是一种专性的细胞内寄生虫，可感染多种温血动物并引起弓形虫病。弓形虫病严重危害人类健康和畜牧业生产。聚类规则间隔短回文重复序列(CRISPR)/CRISPR相关蛋白（Cas）系统作为有效的基因编辑工具之一，已被广泛用于弓形虫基因敲除。本文综述了CRISPR/Cas9技术在弓形虫单基因缺失株和双基因缺失株疫苗中的应用，以期为弓形虫病疫苗的开发提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国血吸虫病防治杂志 Medicine-Medicine (all)

CiteScore

1.30

自引率

0.00%

发文量

7021

期刊介绍： Chinese Journal of Schistosomiasis Control (ISSN: 1005-6661, CN: 32-1374/R), founded in 1989, is a technical and scientific journal under the supervision of Jiangsu Provincial Health Commission and organised by Jiangsu Institute of Schistosomiasis Control. It is a scientific and technical journal under the supervision of Jiangsu Provincial Health Commission and sponsored by Jiangsu Institute of Schistosomiasis Prevention and Control. The journal carries out the policy of prevention-oriented, control-oriented, nationwide and grassroots, adheres to the tenet of scientific research service for the prevention and treatment of schistosomiasis and other parasitic diseases, and mainly publishes academic papers reflecting the latest achievements and dynamics of prevention and treatment of schistosomiasis and other parasitic diseases, scientific research and management, etc. The main columns are Guest Contributions, Experts‘ Commentary, Experts’ Perspectives, Experts' Forums, Theses, Prevention and Treatment Research, Experimental Research, The main columns include Guest Contributions, Expert Commentaries, Expert Perspectives, Expert Forums, Treatises, Prevention and Control Studies, Experimental Studies, Clinical Studies, Prevention and Control Experiences, Prevention and Control Management, Reviews, Case Reports, and Information, etc. The journal is a useful reference material for the professional and technical personnel of schistosomiasis and parasitic disease prevention and control research, management workers, and teachers and students of medical schools. 　　 The journal is now included in important domestic databases, such as Chinese Core List (8th edition), China Science Citation Database (Core Edition), China Science and Technology Core Journals (Statistical Source Journals), and is also included in MEDLINE/PubMed, Scopus, EBSCO, Chemical Abstract, Embase, Zoological Record, JSTChina, Ulrichsweb, Western Pacific Region Index Medicus, CABI and other international authoritative databases.