{"title":"Clinical Phenotype of Behavioral-Variant Frontotemporal Dementia Reversed by ECT: A Case Report.","authors":"Benedict Breitling, Claudia Bartels, Claudia Lange, Caroline Bouter, Hannah Sönne Falk, Jens Wiltfang, David Zilles-Wegner, Matthias Besse","doi":"10.1159/000541668","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Diagnosis of frontotemporal dementia (FTD) remains difficult even in the presence of core clinical and imaging features. Furthermore, disease-modifying treatments are lacking.</p><p><strong>Case presentation: </strong>Here, we report a case of a patient with clinical and imaging features of FTD. Electroconvulsive therapy (ECT) was used to target affective and catatonic symptoms. After ECT, the patient showed improvements not only in affective symptoms but also in cognitive domains, leading to a marked improvement in the patient's level of functioning.</p><p><strong>Conclusion: </strong>Against the background of diagnostic uncertainty and lack of disease-modifying treatments for FTD, we emphasize the importance of focusing on treatable symptoms. Thus, we recommend consideration of ECT as a viable option for multiple symptom domains. In this case of bvFTD, ECT was well-tolerated with relatively low side-effects.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"214-225"},"PeriodicalIF":2.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychobiology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1159/000541668","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Diagnosis of frontotemporal dementia (FTD) remains difficult even in the presence of core clinical and imaging features. Furthermore, disease-modifying treatments are lacking.
Case presentation: Here, we report a case of a patient with clinical and imaging features of FTD. Electroconvulsive therapy (ECT) was used to target affective and catatonic symptoms. After ECT, the patient showed improvements not only in affective symptoms but also in cognitive domains, leading to a marked improvement in the patient's level of functioning.
Conclusion: Against the background of diagnostic uncertainty and lack of disease-modifying treatments for FTD, we emphasize the importance of focusing on treatable symptoms. Thus, we recommend consideration of ECT as a viable option for multiple symptom domains. In this case of bvFTD, ECT was well-tolerated with relatively low side-effects.
期刊介绍：
The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.
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