The impact of setup errors on dose distribution in cervical cancer radiotherapy and the margin from CTV to PTV.

IF 2.7 3区医学 Q3 ONCOLOGY

Journal of Cancer Research and Clinical Oncology Pub Date : 2024-12-02 DOI:10.1007/s00432-024-06032-6

Zhenghuan Li, Yuan Cheng, Jie Dong, Liwan Han, Luxi Chen, Shen Huang, Meifang Zhang, Manya Wu, Fantu Kong, Huamei Yan

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引用次数: 0

Abstract

Purpose: This study calculates the needed margin from clinical target volume (CTV) to planning target volume (PTV) in IMRT for cervical cancer. It also assesses the impact of setup errors on target and organ at risk (OAR) dose distribution.

Methods: We retrospectively analyzed 50 cervical cancer patients who underwent IMRT, with 210 CBCT scans. We calculated the CTV-to-PTV margin and simulated setup errors in the TPS to reassess dose distribution impacts on targets and OAR.

Results: Setup errors in X(anterior-posterior,AP), Y(cranial-caudal,CC), and Z(left-right,LR) directions were (1.4 ± 1.0) mm, (2.3 ± 1.5) mm, and (1.9 ± 1.2) mm, respectively, leading to CTV-to-PTV margins of 4.4 mm, 6.4 mm, and 5.8 mm. X-axis errors did not significantly affect target dosimetry (P > 0.05), but Y and Z errors did (P < 0.05). X-axis errors impacted the small intestine and rectum (P < 0.05), Y-axis errors mainly affected the colon (P < 0.05), and Z-axis errors affected the colon, small intestine, and rectum (P < 0.05).

Conclusion: Our study underscores the need to account for setup errors in radiotherapy for cervical cancer. Customizing the CTV-to-PTV margin based on institutional error data is key to maintaining target dose coverage and optimizing treatment outcomes.

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设置误差对宫颈癌放疗剂量分布及CTV到PTV的影响。

目的：本研究计算宫颈癌IMRT中从临床靶体积（CTV）到计划靶体积（PTV）所需的余量。它还评估了设置误差对靶和危险器官（OAR）剂量分布的影响。方法：回顾性分析50例行IMRT的宫颈癌患者，210例CBCT扫描。我们计算了ctv - ptv裕度，并模拟了TPS中的设置误差，以重新评估剂量分布对目标和桨叶的影响。结果：X（前后，AP）， Y（颅尾，CC）和Z（左右，LR）方向的设置误差分别为（1.4±1.0）mm,(2.3±1.5)mm和（1.9±1.2）mm，导致ctv - ptv边缘分别为4.4 mm， 6.4 mm和5.8 mm。x轴误差对靶剂量测定没有显著影响（P > 0.05），但Y轴和Z轴误差对靶剂量测定有显著影响(P结论：我们的研究强调需要考虑宫颈癌放疗的设置误差。根据机构误差数据定制ctv - ptv范围是维持目标剂量覆盖和优化治疗结果的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cancer Research and Clinical Oncology 医学-肿瘤学

CiteScore

4.00

自引率

2.80%

发文量

577

审稿时长

2 months

期刊介绍： The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.