NRAV promoted the malignant progression of gastric cancer

IF 2.6 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2024-11-29 DOI:10.1016/j.gene.2024.149134

Yuchen Wu , Dongdong Wang , Jie Zhao , Jinhui Guo , Zhenyu Gao , Qiuran Xu , Xiaoge Hu

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引用次数: 0

Abstract

Gastric cancer (GC) has been ranked as the third incidence tumors globally. Long non-coding RNA (lncRNA) NRAV has been reported as a tumor-enhancer in the development of human cancers, whereas the function of NRAV in GC remains to be elucidated. The aim of this research was to explore the underlying function of NRAV in GC. Through comprehensive bioinformatics analysis, a significantly elevation of NRAV was found in both human GC tissues and cell lines, which indicated the poor prognosis of GC patients. Then, we conducted a series of functional experiments to illustrate the role of NRAV in GC. The results showed that the down-regulation of NRAV exhibited a significant inhibitory effect on GC cell proliferation and migration, while NRAV overexpression promoted GC cell proliferation and migration. Through xenograft mouse tumor model, the suppression of NRAV led to a reduction in the growth of tumor mice, whereas overexpression of NRAV notably enhanced tumor growth. Finally, EFHC1 was revealed as the potential target gene of NRAV. Overall, our findings indicated the promising application of NRAV as a therapeutic target and prognostic biomarker for GC.

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NRAV促进胃癌的恶性进展。

胃癌（GC）已成为全球发病率第三高的肿瘤。据报道，长链非编码RNA (lncRNA) NRAV在人类癌症的发展中是一种肿瘤增强剂，而NRAV在GC中的功能仍有待阐明。本研究的目的是探讨NRAV在胃癌中的潜在功能。通过综合生物信息学分析，在人胃癌组织和细胞系中均发现NRAV显著升高，提示胃癌患者预后不良。然后，我们进行了一系列功能实验来说明NRAV在GC中的作用。结果表明，NRAV的下调对胃癌细胞的增殖和迁移有明显的抑制作用，而NRAV的过表达则促进胃癌细胞的增殖和迁移。通过异种移植小鼠肿瘤模型，抑制NRAV可导致肿瘤小鼠生长减少，而过表达NRAV可显著促进肿瘤生长。最后发现EFHC1是NRAV的潜在靶基因。总之，我们的研究结果表明，NRAV作为胃癌的治疗靶点和预后生物标志物具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.