Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis, and regulates Th1 and Th17 cell differentiation.

Abstract

Inflammasomes are associated with various autoimmune diseases. Herein, we aimed to study the occurrence of inflammasomes in peripheral blood mononuclear cells (PBMCs) from patients with autoimmune thyroiditis (AIT), and the relationship between their abundance and the inflammatory response index of AIT. Furthermore, we examined the effect of iodine on inflammasomes containing NLR family pyrin domain containing 3 (NLRP3) and inflammasome activation of helper T cell (Th) differentiation regulation in cultured PBMCs.