Susceptibility of calf lung slice cultures to H5N1 influenza virus.

IF 8.4 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2024-12-09 DOI:10.1080/22221751.2024.2432368

Kate Guilfoyle, Monica Mirolo, Geert van Amerongen, Guido van der Net, Mara Sophie Lombardo, Theresa Störk, Guus Rimmelzwaan, Martin Ludlow, Albert Osterhaus

引用次数: 0

Abstract

ABSTRACTThe current outbreak of HPAI H5N1 virus infections in dairy cattle in the USA underscores the need for easily accessible methods to rapidly assess host susceptibility for infection with known and emerging influenza viruses. Here we show that ex vivo lung slice cultures from calves provide a useful method to rapidly screen host susceptibility to a range of influenza A viruses.

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小牛肺切片培养物对H5N1流感病毒的敏感性。

目前在美国爆发的高致病性H5N1型病毒感染突出表明，需要采用易于获得的方法来快速评估宿主对已知和新出现的流感病毒感染的易感性。本研究表明，小牛离体肺片培养为快速筛选宿主对一系列甲型流感病毒的易感性提供了一种有用的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.