The Rise of Mpox in a Post-Smallpox World.

IF 7.2 2区 医学 Q1 IMMUNOLOGY
Emerging Infectious Diseases Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI:10.3201/eid3101.241230
Jennifer H McQuiston, Andrea McCollum, Athalia Christie, Fernando Torres, Jonathan Mermin, Daniel B Jernigan, Christina L Hutson
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引用次数: 0

Abstract

Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning population immunity after the cessation of routine immunization for smallpox plays a key role in the changing epidemiologic patterns of mpox. Sustained human-to-human transmission of mpox is occurring widely in the context of insufficient population immunity, fueling genetic mutations that affect the accuracy of some diagnostic tests and that could lead to changing virulence. Additional research should address complex challenges for control of mpox, including improved diagnostics and medical countermeasures. The availability of vaccines should be expanded not only for outbreak response but also for broader routine use for persons in mpox-endemic countries.

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来源期刊
Emerging Infectious Diseases
Emerging Infectious Diseases 医学-传染病学
CiteScore
17.30
自引率
1.70%
发文量
505
审稿时长
1 months
期刊介绍: Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.
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