Unveiling a Rarity: First Instance of Urinary Tract Infection Caused by Corynebacterium tuberculostearicum in India.

IF 0.7 Q4 UROLOGY & NEPHROLOGY

Case Reports in Nephrology and Dialysis Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI:10.1159/000542203

Aditya Kundu, Nirmalya Ghosh, Mallika Sengupta, Shiv Sekhar Chatterjee

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引用次数: 0

Abstract

Introduction: Corynebacterium species other than C. diphtheriae are being continuously reported as pathogens.

Case presentation: A patient visited the Urology Outpatient Department of a tertiary care centre in India reporting lower abdominal pain, urinary incontinence, and intermittent weak urine flow persisting for 12 years, intensifying over the last 15 days. She also experienced urgency, straining, weak stream, and incomplete voiding, along with a previous fever episode. The patient had a medical record of multiple urethral dilations and surgeries since 2014, with the most recent urethral dilatation in July 2023. Diagnostic tests revealed a thickened bladder with notable post-void residual urine. Uroflowmetry indicated obstructive uropathy. Urine analysis exhibited elevated leucocytes, epithelial cells, red blood cells, and abundant bacilli. Corynebacterium tuberculostearicum was identified through matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) following three pure growths of Gram-positive bacilli in urine cultures. The organism showed sensitivity to cotrimoxazole and tetracyclines. Treatment with doxycycline significantly improved the symptoms.

Conclusion: The organism Corynebacterium tuberculostearicum is a very rare cause of UTI and the patient responded well to treatment.

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揭示罕见：第一例尿路感染由结核棒状杆菌引起的硬脂质在印度。

导言：除白喉支链杆菌外的棒状杆菌种类不断被报道为病原体。病例介绍：一名患者到印度一家三级保健中心的泌尿科门诊就诊，报告下腹痛、尿失禁和间歇性弱尿流持续12年，在过去15天内加剧。她还经历了尿急、紧张、流弱和不完全排尿，并伴有先前的发烧。患者自2014年以来有多次尿道口扩张和手术病史，最近一次尿道口扩张是在2023年7月。诊断检查显示膀胱增厚，有明显的空后残余尿。尿流仪提示梗阻性尿病。尿液分析显示白细胞、上皮细胞、红细胞和大量杆菌升高。采用基质辅助激光解吸电离飞行时间质谱法（MALDI-TOF MS）对三株革兰氏阳性杆菌的尿液培养物进行鉴定。该菌对复方新诺明和四环素类药物敏感。多西环素治疗可显著改善症状。结论：硬脂结核棒状杆菌是引起尿路感染的一种非常罕见的病原菌，患者对治疗反应良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Nephrology and Dialysis UROLOGY & NEPHROLOGY-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of nephrology and dialysis, including genetic susceptibility, clinical presentation, diagnosis, treatment or prevention, toxicities of therapy, critical care, supportive care, quality-of-life and survival issues. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed.