One-pot synthesis of symmetrical bis-sulfonyl 2,6-diarylpyridines via BiCl3-catalyzed and K2S2O8-mediated domino annulation of β-ketosulfones and N,N-dimethylacetamide.

Abstract

In this study, BiCl₃-promoted and K₂S₂O₈-mediated synthesis of diverse bis-sulfonyl 2,6-diarypyridines was developed via one-pot stepwise (2C + 2C + 1C + 1N) annulation of two molecules of β-ketosulfone and N,N-dimethylacetamide (DMAC). In the entire process, DMAC acts as the synthon of one carbon and one nitrogen in the construction of the pyridine skeleton via cascade formation of single (C-C/C-N) and double (CC/CN) bonds under refluxing DMAC conditions.