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Abstract

Eutypetides A—D (1—4), representing the first class of polycyclic macrolides with 10/6/5 tricyclic ring skeleton, were obtained from the marine-derived fungus Eutypella sp. F0219, together with an intriguing polyketide, eutypetide E (5), containing a novel hexahydroisobenzofuran-1(3H)-one motif. Compounds 1, 2, and 5 were formed biogenetically from 6—8 via intramolecular [4+2] cycloaddition, respectively. More details are discussed in the article by Huang et al. on pages 23—32.