From nuclear to extracellular PTEN: Multiple roles in tumor suppression and immune modulation

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2024-12-02 DOI:10.1016/j.devcel.2024.09.019

Dan Lu, Yuxin Yin

引用次数: 0

Abstract

In this issue of Developmental Cell, Zhang et al. report that secreted PTEN reprograms immunosuppressive tumor-associated macrophages into an inflammatory phenotype by binding to PLXDC2, which enhances antitumor immunity. This Preview discusses diverse functions of PTEN in the nucleus, cytoplasm, and extracellular matrix, highlighting its multifaceted roles in cancer.

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从核到细胞外PTEN：在肿瘤抑制和免疫调节中的多重作用

Zhang等人在本期Developmental Cell中报道，分泌的PTEN通过与PLXDC2结合，将免疫抑制性肿瘤相关巨噬细胞重编程为炎性表型，从而增强抗肿瘤免疫。本预览讨论了PTEN在细胞核、细胞质和细胞外基质中的多种功能，突出了其在癌症中的多方面作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.