{"title":"A fight against cancer with advancement of Schiff base metal complexes: Future prospects","authors":"Monika Tyagi, Monika Dubey","doi":"10.1016/j.oor.2024.100692","DOIUrl":null,"url":null,"abstract":"<div><div>Cancer remains a formidable global health challenge, demanding continuous efforts to develop innovative and effective therapeutic strategies. Recently, Schiff base metal complexes (SBMCs) have attracted considerable interest as potential anticancer agents because of their varied chemical properties and promising biological activities. This comprehensive review delves the latest advancements in the use of SBMCs in cancer therapy. It covers the synthesis and characterization of these complexes, their mechanisms of action, and their potential advantages over conventional chemotherapy. Furthermore, the review discusses challenges and future perspectives in utilizing SBMCs to enhance cancer treatment outcomes, paving the way for a more targeted and personalized approach in the fight against cancer.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100692"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Oncology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772906024005387","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer remains a formidable global health challenge, demanding continuous efforts to develop innovative and effective therapeutic strategies. Recently, Schiff base metal complexes (SBMCs) have attracted considerable interest as potential anticancer agents because of their varied chemical properties and promising biological activities. This comprehensive review delves the latest advancements in the use of SBMCs in cancer therapy. It covers the synthesis and characterization of these complexes, their mechanisms of action, and their potential advantages over conventional chemotherapy. Furthermore, the review discusses challenges and future perspectives in utilizing SBMCs to enhance cancer treatment outcomes, paving the way for a more targeted and personalized approach in the fight against cancer.
癌症仍然是一个巨大的全球健康挑战，需要不断努力制定创新和有效的治疗战略。近年来，希夫碱金属配合物（Schiff base metal complexes, SBMCs）因其多样的化学性质和良好的生物活性而成为潜在的抗癌药物。这篇全面的综述深入研究了sbmc在癌症治疗中的最新进展。它涵盖了这些复合物的合成和表征，它们的作用机制，以及它们相对于传统化疗的潜在优势。此外，本文还讨论了利用sbmc提高癌症治疗效果的挑战和未来前景，为更有针对性和个性化的癌症治疗方法铺平了道路。
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