Construction of water-soluble fluorescent probes supported by carboxymethyl chitosan

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2024-11-28 DOI:10.1016/j.saa.2024.125507

Mei Yang , Xiangxiang Li , Jun Zhang , Chunwei Yu

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Abstract

Two novel Al³⁺ fluorescent probes, CMCS-P₁ and CMCS-P₂, were independently designed and synthesized by modifying the C-2 amino group of carboxymethyl chitosan with benzoyl hydrazide derivatives. The successful incorporation of the benzoyl hydrazide-derived probes was confirmed through FT-IR and ¹H NMR spectroscopy. The sensing performance demonstrated that CMCS-P₁ and CMCS-P₂ could selectively distinguish Al³⁺ from various metal ions, and the proposed probes both demonstrated excellent water solubility and exhibited a highly selective “turn-on” fluorescence response to Al³⁺ in pure aqueous solution. CMCS-P₁ exhibited a broad linear fluorescence response to Al³⁺ concentrations from 1.0 to 20.0 µM, featuring a detection limit of 0.33 µM, CMCS-P₂ displayed a more limited linear response in the range of 3.0–7.0 µM, with a detection limit of 1.0 µM. Additionally, a small-molecule fluorescent probe P₂ was synthesized to explore binding efficiency, and fluorescence imaging in living cells was conducted to successfully detect Al³⁺ with promising results.

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.