A Rapid Pathway to Molecular Complexity: Palladium-Catalyzed Six-Fold Domino Process to Access Polycyclic Frameworks**

Abstract

Herein, we present a hitherto unexplored efficient strategy for rapidly constructing structurally constrained and intriguing polycyclic frameworks with two adjacent quaternary centers. Remarkably, this becomes possible through palladium-catalyzed six-fold domino crossover annulations of simple 1,2-bis(2-bromoaryl)ethynes and 1,2-diarylethynes. Notably, this approach demonstrates the synthesis of both C2-symmetric and unsymmetric polycyclic products.