Emerging roles of cohesin-STAG2 in cancer.

IF 6.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Oncogene Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI:10.1038/s41388-024-03221-y

Julia S Scott, Loubna Al Ayadi, Emmanouela Epeslidou, Roan H van Scheppingen, Anna Mukha, Lucas J T Kaaij, Catrin Lutz, Stefan Prekovic

引用次数: 0

Abstract

Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.

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黏结蛋白stag2在癌症中的新作用。

内聚蛋白是基因组组织的重要调节因子，在维持染色质结构和基因表达方面起着重要作用。在其亚基中，STAG2因其在各种癌症类型（如膀胱癌和黑色素瘤）中频繁发生的有害突变而脱颖而出。STAG2功能的丧失导致染色质结构的显著改变，破坏转录调控，损害DNA修复途径。在这篇综述中，我们探讨了内聚蛋白STAG2功能的分子机制，强调了它在健康细胞中的作用及其对癌症生物学的贡献，揭示了STAG2功能障碍如何促进肿瘤发生，并为靶向治疗干预提供了机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncogene 医学-生化与分子生物学

CiteScore

15.30

自引率

1.20%

发文量

404

审稿时长

1 months

期刊介绍： Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.